Parkinson’s Triple Therapy

Carbidopa/Levodopa/Entacapone

Combination therapy for advanced Parkinson’s to enhance and prolong symptom control.

Carbidopa/Levodopa/Entacapone is a triple combination medication used in the treatment of Parkinson’s disease to manage motor symptoms and reduce “off” times. Levodopa replenishes dopamine levels in the brain, carbidopa enhances levodopa’s bioavailability by preventing its peripheral breakdown, and entacapone inhibits the COMT enzyme, extending levodopa’s duration of action. This comprehensive therapy ensures smoother symptom control throughout the day, particularly in patients with wearing-off effects despite optimized levodopa dosing.

Ingredients dosages:

Frequency:

Quantity:

Not sure about dosages? Don't worry, your provider will adjust or confirm your selection after checkout.

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Here's what happens next:

  1. 1

    Product checkout

    We'll direct you to our product detail page where you can start the checkout process. You'll be charged for the medical consultation but the medication charge is a hold until the official provider review.

  2. 2

    Comprehensive Medical Questionnaire

    After purchase, you'll be directed to a medical assessment covering your medical history, current medications, and specific symptoms.

  3. 3

    Licensed Provider Review

    A licensed healthcare provider reviews your complete medical profile, ensuring this treatment is safe and appropriate for you.

  4. 4

    Personalized Treatment Plan

    Your provider may recommend an adjustment to your prescription based on your full medical profile before approving your treatment.

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  • Significantly reduces “off” time by up to 1.2 hours daily compared to levodopa/carbidopa alone

  • Enhances and prolongs the therapeutic effect of levodopa by inhibiting COMT metabolism

  • Improves motor function, reducing bradykinesia, rigidity, and tremors

  • Provides more consistent and stable control of Parkinson’s symptoms throughout the day

  • Improves patient-reported quality of life and daily functioning in advanced Parkinson’s disease

  • Levodopa: Converts to dopamine in the brain to replenish deficient levels, improving movement and coordination

  • Carbidopa: Inhibits peripheral breakdown of levodopa, increasing its availability in the brain and reducing side effects like nausea

  • Entacapone: COMT inhibitor that prolongs the action of levodopa by preventing its breakdown, extending its duration of effectiveness, and reducing “wearing-off” symptoms

  • Take orally with or without food; avoid high-protein meals close to dosing as they may reduce absorption

  • Swallow tablets whole with water; do not crush or chew

  • Dosage frequency and strength are individualized based on disease severity and treatment response

  • Do not discontinue abruptly; always consult your provider for dose adjustments to prevent symptom worsening