COMT Inhibitor

Entacapone

Medication used with levodopa/carbidopa to enhance Parkinson’s disease symptom control.

Entacapone is a selective and reversible COMT (catechol-O-methyltransferase) inhibitor prescribed as an adjunct to levodopa/carbidopa therapy in patients with Parkinson’s disease experiencing end-of-dose wearing-off symptoms. By inhibiting COMT, it prolongs levodopa activity, improving motor function and reducing fluctuations in symptom control throughout the day.

Ingredients dosages:

Frequency:

Quantity:

Not sure about dosages? Don't worry, your provider will adjust or confirm your selection after checkout.

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Here's what happens next:

  1. 1

    Product checkout

    We'll direct you to our product detail page where you can start the checkout process. You'll be charged for the medical consultation but the medication charge is a hold until the official provider review.

  2. 2

    Comprehensive Medical Questionnaire

    After purchase, you'll be directed to a medical assessment covering your medical history, current medications, and specific symptoms.

  3. 3

    Licensed Provider Review

    A licensed healthcare provider reviews your complete medical profile, ensuring this treatment is safe and appropriate for you.

  4. 4

    Personalized Treatment Plan

    Your provider may recommend an adjustment to your prescription based on your full medical profile before approving your treatment.

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  • Enhances and extends levodopa’s therapeutic effects in Parkinson’s disease

  • Reduces “off” time by up to 30% in patients with motor fluctuations

  • Improves daily motor function and mobility when combined with levodopa/carbidopa

  • Well tolerated when titrated correctly, with gastrointestinal upset as the most common side effect

  • Entacapone: Inhibits COMT enzyme that breaks down levodopa in the periphery, increasing levodopa’s plasma half-life and availability to the brain, thus stabilizing dopamine levels and improving motor symptoms in Parkinson’s disease

  • Take one 200mg tablet with each levodopa/carbidopa dose (up to 8 times daily)

  • Swallow whole, with or without food

  • Follow provider instructions carefully to minimize gastrointestinal side effects

  • Do not stop abruptly; consult your neurologist before dose changes